Optimizing the delivery of chemotherapy in the setting of immunotherapy in a preclinical glioblastoma model

نویسندگان

  • Dimitrios Mathios
  • Jennifer Kim
  • Jillian Phallen
  • Antonella Mangraviti
  • Chul-Kee Park
  • Debebe Theodros
  • Christopher Jackson
  • Tomas Garzon-Muvdi
  • Eileen Kim
  • Xiaobu Ye
  • Betty Tyler
  • Henry Brem
  • Drew Pardoll
  • Michael Lim
چکیده

Background Glioblastoma, despite the use of radiation and chemotherapy, remains vastly lethal. Cancer immunotherapy has entered the era of maturity with new compounds like anti-PD-1 FDA approved to treat advanced tumors. However, the use of immunotherapy in the setting of chemotherapy presents challenges, as chemotherapy causes lymphodepletion and potentially antagonizes immunotherapy. In this work, we studied ways to optimize the delivery of chemotherapy in the setting of immunotherapy.

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2015