Optimizing the delivery of chemotherapy in the setting of immunotherapy in a preclinical glioblastoma model
نویسندگان
چکیده
Background Glioblastoma, despite the use of radiation and chemotherapy, remains vastly lethal. Cancer immunotherapy has entered the era of maturity with new compounds like anti-PD-1 FDA approved to treat advanced tumors. However, the use of immunotherapy in the setting of chemotherapy presents challenges, as chemotherapy causes lymphodepletion and potentially antagonizes immunotherapy. In this work, we studied ways to optimize the delivery of chemotherapy in the setting of immunotherapy.
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